3 playthroughs. Thousands of hours. First, a male nomad with 1-2 k hours. Second, a female street kid with 1 - 1.5 k hours and thirdly a male/female corpo with 1-2 k hours depending if they make a good coop then I'd use corpo dude for coop mostly and play singleplayer with my nomad (mostly) and street kid.
Spent 2.5k hours in skyrim, a thousand hours in Witcher 3 so I have no doubth I'll have at least 3 playthroughs and over 3 thousand hours in this game.