Originally posted by Sardukhar:

Looks that way? Sort-of.

Humanity as a cyberlimiter for V has been, apparently, scrapped. But as the 2018 trailer indicates, Cyberpsychosis and Max Tac are still a thing.
So I would say Humanity and Empathy are still an in world thing, just not part of V's character options.

Very few players in any game I ran went c-psycho anyway. They would get close and then get therapy or trade out cyberware with therapy to afford the new one. It's a cool mechanic and a good limiter, but in practicality, you rarely saw Player Characters go nuts

Probably affect dialogue and social interaction. That was the important part of Empathy for me. The limit to Human Perception, Fast/Talk, etc.